Genomics-Guided Discovery of Endophenazines from Kitasatospora sp. HKI 714

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• 作者：Daniel Heine ; Karin Martin ; Christian Hertweck
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：April 25, 2014
• 年：2014
• 卷：77
• 期：4
• 页码：1083-1087
• 全文大小：247K
• 年卷期：v.77,no.4(April 25, 2014)
• ISSN：1520-6025

文摘

In this study we report on the genomics-guided exploration of the metabolic potential of the newly discovered strain Kitasatospora sp. HKI 714. The bioinformatics analysis of the whole genome sequence revealed the presence of a biosynthetic gene cluster presumably responsible for the biosynthesis of formerly unknown endophenazine derivatives. A 200 L cultivation combined with bioactivity-guided isolation techniques revealed four new natural products belonging to the endophenazines and the 5,10-dihydrophenazines. Detailed descriptions of their biological effects, mainly focused on antimicrobial properties against several mycobacteria, are given.