Efficient Asymmetric α-Oxyamination of Aldehydes by Resin-Supported Peptide Catalyst in Aqueous Media

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• 作者：Kengo Akagawa ; Takuma Fujiwara ; Seiji Sakamoto ; Kazuaki Kudo
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：April 16, 2010
• 年：2010
• 卷：12
• 期：8
• 页码：1804-1807
• 全文大小：279K
• 年卷期：v.12,no.8(April 16, 2010)
• ISSN：1523-7052

文摘

The resin-supported peptide catalyst having the terminal five-residue Pro-d-Pro-Aib-Trp-Trp combined with polyleucine successfully catalyzed the asymmetric α-oxyamination of aldehydes in aqueous media. The secondary structure and the chirality sense of the hydrophobic polyleucine chain significantly affected both reactivity and enantioselectivity.