Encapsulation of a Radiolabeled Cluster Inside a Fullerene Cage, 177LuxLu(3−x)N@C80: An Interleukin-13-Conjugated Radiolabeled Metallofu

详细信息    查看全文

• 作者：Michael D. Shultz ; James C. Duchamp ; John D. Wilson ; Chun-Ying Shu ; Jiechao Ge ; Jianyuan Zhang ; Harry W. Gibson ; Helen L. Fillmore ; Jerry I. Hirsch ; Harry C. Dorn ; Panos P. Fatouros
• 刊名：Journal of the American Chemical Society
• 出版年：2010
• 出版时间：April 14, 2010
• 年：2010
• 卷：132
• 期：14
• 页码：4980-4981
• 全文大小：131K
• 年卷期：v.132,no.14(April 14, 2010)
• ISSN：1520-5126

文摘

In this communication, we describe the successful encapsulation of ¹⁷⁷Lu into the endohedral metallofullerene ¹⁷⁷Lu_xLu_3−xN@C₈₀ (x = 1−3) starting with ¹⁷⁷LuCl₃ in a modified quartz Krschmer−Huffman electric generator. We demonstrate that the ¹⁷⁷Lu (β-emitter) in this fullerene cage is not significantly released for a period of up to at least one-half-life (6.7 days). We also demonstrate that this agent can be conjugated with an interleukin-13 peptide that is designed to target an overexpressed receptor in glioblastoma multiforme tumors. This nanoparticle delivery platform provides flexibility for a wide range of radiotherapeutic and radiodiagnostic multimodal applications.