Synthesis and Antiviral Activities of Phenanthroindolizidine Alkaloids and Their Derivatives

详细信息    查看全文

• 作者：Kailiang Wang ; Bo Su ; Ziwen Wang ; Meng Wu ; Zheng Li ; Yanna Hu ; Zhijin Fan ; Na Mi ; Qingmin Wang
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2010
• 出版时间：March 10, 2010
• 年：2010
• 卷：58
• 期：5
• 页码：2703-2709
• 全文大小：813K
• 年卷期：v.58,no.5(March 10, 2010)
• ISSN：1520-5118

文摘

Racemic phenanthroindolizidine alkaloids tylophorine, antofine, and deoxytylophorinine, and optically pure alkaloids S-(+)-tylophorine and R-(−)-tylophorine were synthesized and evaluated for their antiviral activities against tobacco mosaic virus (TMV). Further salinization modifications based on tylophorine increased stability and water solubility and improved the antiviral activity in application. The bioassay results showed that most of these synthesized compounds showed higher antiviral activity against TMV in vitro and in vivo than commercial Ningnanmycin. Especially, tylophorine salt derivatives 10, 11, 13, 17, and 22 emerged as potential inhibitors of plant virus. These findings demonstrate that these phenanthroindolizidine alkaloids and their salt derivatives represent a new template for antiviral studies and could be considered for novel therapy against plant virus infection.