Biodefunctionalization of Functionalized Single-Walled Carbon Nanotubes in Mice

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• 作者：Sheng-Tao Yang ; Haifang Wang ; Mohammed J. Meziani ; Yuanfang Liu ; Xin Wang ; Ya-Ping Sun
• 刊名：Biomacromolecules
• 出版年：2009
• 出版时间：July 13, 2009
• 年：2009
• 卷：10
• 期：7
• 页码：2009-2012
• 全文大小：134K
• 年卷期：v.10,no.7(July 13, 2009)
• ISSN：1526-4602

文摘

Chemically modified carbon nanotubes with hydrophilic functionalities such as polyethylene glycols (PEGs) are widely pursued for potential biological and biomedical applications. In this study, PEGylated single-walled carbon nanotubes (PEG-SWNT) were intravenously administrated into mice to study their biodefunctionalization in vivo by using complementary Raman and photoluminescence measurements. There was meaningful defunctionalization of PEG-SWNT in liver over time, but not in spleen under similar conditions. The evidence from spectroscopic characterization and analyses is presented, and mechanistic implications are discussed.