Quantitative Differential Proteome Analysis in an Animal Model for Human Melanoma

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• 作者：Katrin Lokaj^† ; ^# ; Svenja Meierjohann^# ; Claudia Schtz^† ; ; Janka Teutschbein ; Manfred Schartl ; Albert Sickmann*^&#
• 刊名：Journal of Proteome Research
• 出版年：2009
• 出版时间：April 3, 2009
• 年：2009
• 卷：8
• 期：4
• 页码：1818-1827
• 全文大小：706K
• 年卷期：v.8,no.4(April 3, 2009)
• ISSN：1535-3907

文摘

In fish of the genus Xiphophorus, different grades of pigment cell lesions from nevi to melanoma can be gained by simple crossbreeding. With this model, one can easily access tissues of different malignancies from animals with highly identical genetic background. To find protein expression differences between healthy, benign and malignant tissues, we performed 2D PAGE and DIGE and found among regulated proteins antioxidant proteins that were overexpressed with increasing malignancy.