seco-Abietane Diterpenoids, a Phenylethanoid Derivative, and Antitubercular Constituents from Callicarpa pilosissima

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• 作者：Jih-Jung Chen*^† ; ; Hung-Ming Wu^† ; ; Chien-Fang Peng^‡ ; ; Ih-Sheng Chen^§ ; ; Shih-Der Chu^† ;
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：February 27, 2009
• 年：2009
• 卷：72
• 期：2
• 页码：223-228
• 全文大小：155K
• 年卷期：v.72,no.2(February 27, 2009)
• ISSN：1520-6025

文摘

Six new compounds, including five new seco-abietane diterpenoids, 12-deoxy-seco-hinokiol methyl ester (1), 12-deoxy-11,12-dihydro-seco-hinokiol methyl ester (2), callicarpic acid A (3), 9α-hydroxycallicarpic acid A (4), and callicarpic acid B (5), and a new phenylethanoid derivative, 4-hydroxyphenethyl tetradecanoate (6), have been isolated from the leaves and twigs of Callicarpa pilosissima, together with 14 known compounds (7−20). The structures of these new compounds were determined through analyses of physical data. 12-Deoxy-11,12-dihydro-seco-hinokiol methyl ester (2), callicarpic acid B (5), and α-tocopherol trimer B (15) exhibit antitubercular activities (MICs ≤ 63.6 μM) against Mycobacterium tuberculosis H₃₇Rv in vitro.