Microwave-Assisted Fluorous Synthesis of a 1,4-Benzodiazepine-2,5-dione Library

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• 作者：Aifeng Liu ; Hongyu Zhou ; Gaoxing Su ; Wei Zhang ; Bing Yan
• 刊名：Journal of Combinatorial Chemistry
• 出版年：2009
• 出版时间：November 9, 2009
• 年：2009
• 卷：11
• 期：6
• 页码：1083-1093
• 全文大小：295K
• 年卷期：v.11,no.6(November 9, 2009)
• ISSN：1520-4774

文摘

Fluorous displaceable linker-facilitated synthesis of 1,4-benzodiazepine-2,5-dione library has been developed. Perfluorooctanesulfonyl protected 4-hydroxy benzaldehydes were used as the limiting agent for Ugi four-component reactions to form condensed products. Postcondensation reactions of the Ugi products generated 1,4-benzodiazepine-2,5-dione ring skeleton. Microwave-assisted Suzuki coupling reactions removed the fluorous tag and introduced biaryl functionality to the benzodiazepine ring. The library scaffold has four points of substitution diversities. The fluorous tag facilitated the intermediate purifications using fluorous solid-phase extraction (F-SPE) and had no negative impact on the reactivity of the Ugi reactions and postcondensation reactions.