Bioactive Sulfated Sesterterpene Alkaloids and Sesterterpene Sulfates from the Marine Sponge Fasciospongia sp.

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• 作者：Guangmin Yao^† ; ^§ ; ; Tamara P. Kondratyuk^‡ ; ; Ghee T. Tan^‡ ; ; John M. Pezzuto^‡ ; ; Leng Chee Chang*^‡ ;
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：February 27, 2009
• 年：2009
• 卷：72
• 期：2
• 页码：319-323
• 全文大小：119K
• 年卷期：v.72,no.2(February 27, 2009)
• ISSN：1520-6025

文摘

Two new sulfated sesterterpene alkaloids, 19-oxofasciospongine A (3) and fasciospongine C (4), and a new sesterterpene sulfate, 25-hydroxyhalisulfate 9 (5), along with two known sesterterpene sulfates, halisulfates 7 (6) and 9 (7), were isolated from an organic extract of the marine sponge Fasciospongia sp. The structures of the new compounds were established on the basis of one- and two-dimensional NMR spectroscopic studies as well as by HRESIMS analysis. Compounds 1−7 exhibited inhibitory activity against Streptomyces 85E in the hyphae-formation inhibition assay. Compounds 1, 2, and 4−7 were not cytotoxic when tested at 20 μg/mL with MCF-7, LNCaP, and LU cell lines. Only compound 3 demonstrated a moderate cytotoxic effect on the MCF-7 (IC₅₀ 13.4 μM), LNCaP (IC₅₀ 21.8 μM), and LU-1 cells (IC₅₀ 5.0 μM), respectively.