Benzophenone Derivatives from the Fruits of Garcinia multiflora and Their Anti-inflammatory Activity

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• 作者：Jih-Jung Chen*^† ; ; Chia-Wei Ting^† ; ; Tsong-Long Hwang^‡ ; ; Ih-Sheng Chen^&#167 ;
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：February 27, 2009
• 年：2009
• 卷：72
• 期：2
• 页码：253-258
• 全文大小：224K
• 年卷期：v.72,no.2(February 27, 2009)
• ISSN：1520-6025

文摘

Five new benzophenone derivatives, 13,14-didehydoxyisogarcinol (1), garcimultiflorone A (2), garcimultiflorone B (3), 13-hydroxygarcimultiflorone B (4), and garcimultiflorone C (5), have been isolated from the fruits of Garcinia multiflora, together with seven known compounds (6−12). The structures of these new compounds were determined through spectroscopic and MS analyses. 13,14-Didehydoxyisogarcinol (1), garcimultiflorone A (2), garcimultiflorone B (3), and 13-hydroxygarcimultiflorone B (4) exhibited inhibition with an IC₅₀ range of 0.11−5.58 μM on superoxide anion generation and elastase release by human neutrophils in response to fMet-Leu-Phe/cytochalasin B (fMLP/CB).