Toxicological Effect of ZnO Nanoparticles Based on Bacteria

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• 作者：Zhongbing Huang ; Xu Zheng ; Danhong Yan ; Guangfu Yin ; Xiaoming Liao ; Yunqing Kang ; Yadong Yao ; Di Huang ; Baoqing Hao
• 刊名：Langmuir
• 出版年：2008
• 出版时间：April 15, 2008
• 年：2008
• 卷：24
• 期：8
• 页码：4140 - 4144
• 全文大小：583K
• 年卷期：v.24,no.8(April 15, 2008)
• ISSN：1520-5827

文摘

Streptococcus agalactiae and Staphylococcus aureus are two pathogenetic agents of several infective diseases inhumans. Biocidal effects and cellular internalization of ZnO nanoparticles (NPs) on two bacteria are reported, andZnO NPs have a good bacteriostasis effect. ZnO NPs were synthesized in the EG aqueous system through the hydrolysisof ionic Zn²⁺ salts. Particle size and shape were controlled by the addition of the various surfactants. Bactericidaltests were performed in an ordinary broth medium on solid agar plates and in liquid systems with different concentrationsof ZnO NPs. The biocidal action of ZnO materials was studied by transmission electron microscopy of bacteriaultrathin sections. The results confirmed that bactericidal cells were damaged after ZnO NPs contacted with them,showing both gram-negative membrane and gram-positive membrane disorganization. The surface modification ofZnO NPs causes an increase in membrane permeability and the cellular internalization of these NPs whereas thereis a ZnO NP structure change inside the cells.