• 作者：Bor-Cherng Hong ; Roshan Y. Nimje ; Amit A. Sadani ; Ju-Hsiou Liao
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：June 19, 2008
• 年：2008
• 卷：10
• 期：12
• 页码：2345 - 2348
• 全文大小：244K
• 年卷期：v.10,no.12(June 19, 2008)
• ISSN：1523-7052

Organocatalytic Michael reaction of glutaraldehyde and 3-arylpropenal followed by the subsequent intramolecular aldol condensation provided 2-arylcyclohex-3-ene-1,3-dicarbaldehydes. Reactions with the 5-oxohexanal variant afforded the highly functionalized cyclohexenedicarbaldehydes in high diastereoselectivity and high enantioselectivity (>99% ee). Structure of the adduct 3j was confirmed unambiguously by X-ray analysis.