An Expedient Synthesis of the Fibril Binding Compound FSB via Sequential Pd-Catalyzed Coupling Reactions
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- 作者：Mette Louise H. Mantel ; Lina S. Sø ; bjerg ; Tri H. V. Huynh ; Jean-Philippe Ebran ; Anders T. Lindhardt (né ; Hansen) ; Niels C. Nielsen ; Troels Skrydstrup
- 刊名：Journal of Organic Chemistry
- 出版年：2008
- 出版时间：May 2, 2008
- 年：2008
- 卷：73
- 期：9
- 页码：3570 - 3573
- 全文大小：208K
- 年卷期：v.73,no.9(May 2, 2008)
- ISSN：1520-6904
文摘
The styryl benzene derivative (E,E)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (FSB), well-known for its binding to β-amyloid peptide fibrils, was synthesized in an efficient manner exploiting two sequential palladium(0)-catalyzed coupling reactions in a 34% overall yield. This is a substantial improvement to the previously reported synthesis of FSB in 1.1%.