Polyacrylate-Coated SPME Fibers as a Tool To Simulate Body Residues and Target Concentrations of Complex Organic Mixtures for Estimation of Baseline Toxicity

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• 作者：Eric M. J. Verbruggen ; Wouter H. J. Vaes ; Thomas F. Parkerton ; and Joop L. M. Hermens
• 刊名：Environmental Science & Technology
• 出版年：2000
• 出版时间：January 15, 2000
• 年：2000
• 卷：34
• 期：2
• 页码：324 - 331
• 全文大小：85K
• 年卷期：v.34,no.2(January 15, 2000)
• ISSN：1520-5851

文摘

The acute toxicity of narcotic organic chemical mixturesis related to the total molar concentration within organisms.In this study, the use of polyacrylate SPME fibers isinvestigated for the purpose of biomimetic extractions, aprocedure used to simulate bioconcentration and to estimatetotal concentrations in aquatic organisms. ExperimentalSPME-water partition coefficients correlate well withoctanol-water and membrane-water partition coefficients,indicating that these passive sampling devices provide agood surrogate for lipid partitioning. On the basis of theserelationships, the total internal concentration resultingfrom exposure to an aqueous sample can be estimatedfrom the total moles of chemicals that sorb to the fiber. Theaquatic toxicity of the sample is then predicted bycomparison to critical internal concentrations that elicitadverse effects. This procedure offers a number of practicaladvantages over previous biomimetic extraction techniques(e.g., Empore disk) due to faster sorption kinetics, smallersample volumes, and applicability to volatile compounds.