Assembly, Two-Photon Absorption, and Bioimaging of Living Cells of A Cuprous Cluster

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• 作者：Xuchun Wang ; Xiaohe Tian ; Qiong Zhang ; Pingping Sun ; Jieying Wu ; Hongping Zhou ; Baokang Jin ; Jiaxiang Yang ; Shengyi Zhang ; Chuankui Wang ; Xutang Tao ; Minhua Jiang ; Yupeng Tian
• 刊名：Chemistry of Materials
• 出版年：2012
• 出版时间：March 13, 2012
• 年：2012
• 卷：24
• 期：5
• 页码：954-961
• 全文大小：423K
• 年卷期：v.24,no.5(March 13, 2012)
• ISSN：1520-5002

文摘

A novel cuprous(I) cluster Cu₄I₄L₄ (L = (E)-(4-diethylanilino-styryl)pyridine) bearing strong two-photon absorption (TPA) was obtained using a facile assembly method, and the crystal structure has been determined. Quantum chemical calculations using time-dependent density functional theory (TD-DFT) reveals that the combination of the organic ligands with the three-dimensional Cu₄I₄ core extends the electronic delocalization in the cluster, leading to strong two-photon absorption action. The TPA cross sections (桅蟽₂) of Cu₄I₄L₄ were enhanced with increasing polarity of solvents, which is quite different from the solvent effects on TPA in the literature. Compared to its free ligand, the cluster Cu₄I₄L₄ exhibits larger peak TPA cross sections in the near-infrared region, longer fluorescence lifetimes, higher quantum yield and photostability, lower cytotoxicity, and brighter two-photon fluorescent (TPF) bioimaging. These integrated advantages make it desirable to be applied as a two-photon fluorescent probe for labeling the nucleic acids in live cells.

Keywords:

assembly; two-photon absorption; bioimaging; cuprous cluster