Biologically Compatible, Phosphorescent Dimetallic Rhenium Complexes Linked through Functionalized Alkyl Chains: Syntheses, Spectroscopic Properties, and Applications in Imaging Microscopy

详细信息    查看全文

• 作者：Rebeca G. Balasingham ; Flora L. Thorp-Greenwood ; Catrin F. Williams ; Michael P. Coogan ; Simon J. A. Pope
• 刊名：Inorganic Chemistry
• 出版年：2012
• 出版时间：February 6, 2012
• 年：2012
• 卷：51
• 期：3
• 页码：1419-1426
• 全文大小：351K
• 年卷期：v.51,no.3(February 6, 2012)
• ISSN：1520-510X

文摘

A range of luminescent, dimetallic complexes based upon the rhenium fac-tricarbonyl diimine core, linked by aliphatic chains of varying lengths and functionality, have been synthesized and their photophysical properties examined. Each complex displays characteristic ³M_ReL_diimineCT emission in aerated acetonitrile solution, with long lifetimes in the range of 129鈥?48 ns and corresponding quantum yields in the range 3.2鈥?.0%. In aqueous solution, as opposed to acetonitrile, the complexes generally show a small hypsochromic shift in 位_em and an extension of the ³MLCT lifetime, attributed to a hydrophobically driven association of the alkyl chains with the rhenium-bound diimine units. In live cell imaging experiments using MCF7 cells the complexes all show good uptake by non-energy dependent mechanisms without endosomal entrainment, and with varying propensity to localize in organelles. The degrees of uptake and localization properties are discussed in terms of the length and chemical nature of the linkers, and in terms of the likely interactions between these and the various cellular components encountered.