Organophosphate Pesticide Exposure and Neurodevelopment in Young Shanghai Children

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• 作者：Ding Guodong ; Wang Pei ; Tian Ying ; Zhang Jun ; Gao Yu ; Wang Xiaojin ; Shi Rong ; Wang Guoquan ; Shen Xiaoming
• 刊名：Environmental Science & Technology (ES&T)
• 出版年：2012
• 出版时间：March 6, 2012
• 年：2012
• 卷：46
• 期：5
• 页码：2911-2917
• 全文大小：206K
• 年卷期：v.46,no.5(March 6, 2012)
• ISSN：1520-5851

文摘

A large amount of organophosphate pesticides (OPs) is used throughout China. Animal studies have suggested that even moderate doses are toxic to neurodevelopment, but there are a few studies in humans. We investigated both the urinary levels of OP metabolites in children and their relationship with child neurodevelopment. Participating 301 young children (23鈥?5 months of age) were recruited from two community hospitals in Shanghai between February and October 2008. We measured five nonspecific dialkyl phosphate (DAP) metabolite levels of OPs in the children鈥檚 urine and examined their association with the children鈥檚 developmental quotients (DQs) based on the Gesell Developmental Schedules (GDS). The creatinine-adjusted geometric means (GMs) of OP metabolites in urine samples were 11.27 渭g/g for DMP; 6.99 渭g/g for DMTP; 7.96 渭g/g for DEP; 14.19 渭g/g for DETP; and 4.55 渭g/g for DEDTP. The children had relatively higher levels of OP urinary metabolites compared with those reported in developed countries, no association was found between child urinary levels of OP metabolites and any of the DQ scores. However, our results should be interpreted with caution, and more studies of children living in China are warranted given the relatively high levels of child OP urinary metabolites in Shanghai.