Cytotoxic Angucycline Class Glycosides from the Deep Sea Actinomycete Streptomyces lusitanus SCSIO LR32

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• 作者：Hongbo Huang ; Tingting Yang ; Xiangmei Ren ; Jing Liu ; Yongxiang Song ; Aijun Sun ; Junying Ma ; Bo Wang ; Yun Zhang ; Caiguo Huang ; Changsheng Zhang ; Jianhua Ju
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：February 24, 2012
• 年：2012
• 卷：75
• 期：2
• 页码：202-208
• 全文大小：332K
• 年卷期：v.75,no.2(February 24, 2012)
• ISSN：1520-6025

文摘

Five new C-glycoside angucyclines, named grincamycins B鈥揊 (1鈥?b>5), and a known angucycline antibiotic, grincamycin (6), were isolated from Streptomyces lusitanus SCSIO LR32, an actinomycete of deep sea origin. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses, including MS and 1D and 2D NMR experiments. All compounds except grincamycin F (5) exhibited in vitro cytotoxicities against the human cancer cell lines HepG2, SW-1990, HeLa, NCI-H460, and MCF-7 and the mouse melanoma cell line B16, with IC₅₀ values ranging from 1.1 to 31 渭M.