Phaeosphaerins A鈥揊, Cytotoxic Perylenequinones from an Endolichenic Fungus, Phaeosphaeria sp.

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• 作者：Gang Li ; Haiying Wang ; Rongxiu Zhu ; Lingmei Sun ; Lining Wang ; Ming Li ; Yaoyao Li ; Yongqing Liu ; Zuntian Zhao ; Hongxiang Lou
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：February 24, 2012
• 年：2012
• 卷：75
• 期：2
• 页码：142-147
• 全文大小：315K
• 年卷期：v.75,no.2(February 24, 2012)
• ISSN：1520-6025

文摘

Six novel phototoxins, phaeosphaerins A鈥揊 (1鈥?b>6), together with six known perylenequinones were isolated from an endolichenic fungus Phaeosphaeria sp. Their structures were determined unequivocally on the basis of comprehensive analysis of MS and NMR data as well as electronic circular dichroism calculations. These toxins kill cancer cells in vitro with accumulation in lysosomes, and the killing effects were potently intensified in the presence of light.