Gold-Catalyzed Furan/Yne Cyclizations for the Regiodefined Assembly of Multisubstituted Protected 1-Naphthols

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• 作者：Chengyu Wang ; Yifeng Chen ; Xin Xie ; Jun Liu ; Yuanhong Liu
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：February 17, 2012
• 年：2012
• 卷：77
• 期：4
• 页码：1915-1921
• 全文大小：343K
• 年卷期：v.77,no.4(February 17, 2012)
• ISSN：1520-6904

文摘

The gold(I)-catalyzed intramolecular cycloisomerization of furan/ynes bearing a silyloxy or allyloxy group has been developed, which provides a highly efficient access to protected 1-naphthol derivatives with enal or enone moiety. The method offers several advantages such as high stereoselectivities, mild reaction conditions, and easily accessible starting materials. In addition, the naphthyl products could be further transformed into the important benzocoumarins in a one-pot procedure.