Standard Guidelines for the Chromosome-Centric Human Proteome Project

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• 作者：Young-Ki Paik ; Gilbert S. Omenn ; Mathias Uhlen ; Samir Hanash ; Gy枚rgy Marko-Varga ; Ruedi Aebersold ; Amos Bairoch ; Tadashi Yamamoto ; Pierre Legrain ; Hyoung-Joo Lee ; Keun Na ; Seul-Ki Jeong ; Fuchu He ; Pierre-Alain Binz ; Toshihide Nishimura ; Paul Keown ; Mark S. Baker ; Jong Shin Yoo ; Jerome Garin ; Alexander Archakov ; John Bergeron ; Ghasem Hosseini Salekdeh ; William S. Hancock
• 刊名：Journal of Proteome Research
• 出版年：2012
• 出版时间：April 6, 2012
• 年：2012
• 卷：11
• 期：4
• 页码：2005-2013
• 全文大小：408K
• 年卷期：v.11,no.4(April 6, 2012)
• ISSN：1535-3907

文摘

The objective of the international Chromosome-Centric Human Proteome Project (C-HPP) is to map and annotate all proteins encoded by the genes on each human chromosome. The C-HPP consortium was established to organize a collaborative network among the research teams responsible for protein mapping of individual chromosomes and to identify compelling biological and genetic mechanisms influencing colocated genes and their protein products. The C-HPP aims to foster the development of proteome analysis and integration of the findings from related molecular -omics technology platforms through collaborations among universities, industries, and private research groups. The C-HPP consortium leadership has elicited broad input for standard guidelines to manage these international efforts more efficiently by mobilizing existing resources and collaborative networks. The C-HPP guidelines set out the collaborative consensus of the C-HPP teams, introduce topics associated with experimental approaches, data production, quality control, treatment, and transparency of data, governance of the consortium, and collaborative benefits. A companion approach for the Biology and Disease-Driven HPP (B/D-HPP) component of the Human Proteome Project is currently being organized, building upon the Human Proteome Organization's organ-based and biofluid-based initiatives (www.hupo.org/research). The common application of these guidelines in the participating laboratories is expected to facilitate the goal of a comprehensive analysis of the human proteome.

Keywords:

antibody; Biology/Disease-Driven Human Proteome Project; Chromosome-Centric Human Proteome Project; Human Genome Project; Human Proteome Project; Human Proteome Organization; knowledge-base; mass spectrometry