AlMe3-Promoted Formation of Amides from Acids and Amines

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• 作者：Jianqing Li ; Krishnananthan Subramaniam ; Daniel Smith ; Jennifer X. Qiao ; Jie Jack Li ; Jingfang Qian-Cutrone ; John F. Kadow ; Gregory D. Vite ; Bang-Chi Chen
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：January 6, 2012
• 年：2012
• 卷：14
• 期：1
• 页码：214-217
• 全文大小：224K
• 年卷期：v.14,no.1(January 6, 2012)
• ISSN：1523-7052

文摘

In the presence of AlMe₃, amines can be directly coupled with acids through dimethylaluminum amide intermediates to form the corresponding amides. A wide range of amines and acids including less nucleophilic amines, bulky amines, unprotected secondary amino acids, and acids with poor solubility were coupled smoothly to give the desired products in 55鈥?8% yields.