Synthesis of New 4,5-Dihydrofuranoindoles and Their Evaluation as HCV NS5B Polymerase Inhibitors

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• 作者：Francisco Vel谩zquez ; Srikanth Venkatraman ; Charles A. Lesburg ; Jos茅 Duca ; Stuart B. Rosenblum ; Joseph A. Kozlowski ; F. George Njoroge
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：January 20, 2012
• 年：2012
• 卷：14
• 期：2
• 页码：556-559
• 全文大小：264K
• 年卷期：v.14,no.2(January 20, 2012)
• ISSN：1523-7052

文摘

The synthesis of substituted 3,4-dihydrofuranoindoles is reported. These new indole compounds were used to synthesize potent HCV NS5B inhibitors. The binding mode of the dihydrofuranoindole-derived inhibitors was established via X-ray crystallographic studies.