Preparation of Redox-Sensitive Shell Cross-Linked Nanoparticles for Controlled Release of Bioactive Agents

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• 作者：Guohua Jiang ; Yin Wang ; Rui Zhang ; Rijing Wang ; Xiaohong Wang ; Ming Zhang ; Xinke Sun ; Shiyong Bao ; Tao Wang ; Sheng Wang
• 刊名：ACS Macro Letters
• 出版年：2012
• 出版时间：April 17, 2012
• 年：2012
• 卷：1
• 期：4
• 页码：489-493
• 全文大小：302K
• 年卷期：v.1,no.4(April 17, 2012)
• ISSN：2161-1653

文摘

Redox-sensitive shell cross-linked (SCL) poly(2-(dimethylamino)ethyl methacrylate)-block-polystyrene (PDMAEMA-b-PS) nanoparticles have been facilely fabricated by surfactant-free emulsion reversible addition鈥揻ragmentation chain transfer polymerization (SFE-RAFT), in which amphiphilic C₁₂H₂₅鈥揚DMAEMA copolymers acted as stabilizers. ¹H NMR, dynamic light scattering (DLS), and transmission electron microscopy (TEM) were applied to investigate the compositions and the morphologies of the resultant nanoparticles. Then, the as-prepared nanoparticles were used as a carrier to encapsulate of hydrophobic drugs, and the release could be triggered by a redox reagent, dithiothreitol (DTT). The SCL nanoparticles had a good biocompatibility. These properties indicated that these nanoparticles would be used as promising drug delivery vehicles.