Facile Functionalization of Polyesters through Thiol-yne Chemistry for the Design of Degradable, Cell-Penetrating and Gene Delivery Dual-Functional Agents

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• 作者：Zhonghai Zhang ; Lichen Yin ; Yunxiang Xu ; Rong Tong ; Yanbing Lu ; Jie Ren ; Jianjun Cheng
• 刊名：Biomacromolecules
• 出版年：2012
• 出版时间：November 12, 2012
• 年：2012
• 卷：13
• 期：11
• 页码：3456-3462
• 全文大小：412K
• 年卷期：v.13,no.11(November 12, 2012)
• ISSN：1526-4602

文摘

Synthesis of polyesters bearing pendant amine groups with controlled molecular weights and narrow molecular weight distributions was achieved through ring-opening polymerization of 5-(4-(prop-2-yn-1-yloxy)benzyl)-1,3-dioxolane-2,4-dione, an O-carboxyanhydride derived from tyrosine, followed by thiol-yne 鈥渃lick鈥?photochemistry with 2-aminoethanethiol hydrochloride. This class of biodegradable polymers displayed excellent cell penetration and gene delivery properties with low toxicities.