Aptamer-Capped Multifunctional Mesoporous Strontium Hydroxyapatite Nanovehicle for Cancer-Cell-Responsive Drug Delivery and Imaging

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• 作者：Zhenhua Li ; Zhen Liu ; Meili Yin ; Xinjian Yang ; Qinghai Yuan ; Jinsong Ren ; Xiaogang Qu
• 刊名：Biomacromolecules
• 出版年：2012
• 出版时间：December 10, 2012
• 年：2012
• 卷：13
• 期：12
• 页码：4257-4263
• 全文大小：371K
• 年卷期：v.13,no.12(December 10, 2012)
• ISSN：1526-4602

文摘

A novel cancer-cells-triggered controlled-release gadolinium-doped luminescent and mesoporous strontium hydroxyapatite nanorods (designated as Gd:SrHap nanorods) system using cell-type-specific aptamers as caps has been constructed. Aptamers behave as a dual-functional molecule that acts as not only a lid but also a targeted molecular that can be used in an effective way for therapeutically special cancer cells. After incubated with cancer cells, for example, MCF-7 cells, the doxorubicin-loaded and aptamer-capped Gd:SrHap nanorods (designated as Gd:SrHap-Dox-aptamer) can be internalized into MCF-7 cells, resulting in the pore opening and drug releasing. Furthermore, the high biocompatibility and biodegradability Gd:SrHap nanorods with blue autofluorescence and paramagnetism could serve as a good contrast agent of targeting fluorescence and magnetic resonance imaging. We envision that this Gd:SrHap system could play a significant role in developing new generations of site-selective, controlled-release delivery and interactive sensory nanodevices.