Design and Optical Trapping of a Biocompatible Propeller-like Nanoscale Hybrid

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• 作者：Jaekwon Do ; Robert Schreiber ; Andrey A. Lutich ; Tim Liedl ; Jessica Rodr铆guez-Fern谩ndez ; Jochen Feldmann
• 刊名：Nano Letters
• 出版年：2012
• 出版时间：September 12, 2012
• 年：2012
• 卷：12
• 期：9
• 页码：5008-5013
• 全文大小：403K
• 年卷期：v.12,no.9(September 12, 2012)
• ISSN：1530-6992

文摘

Designing nanoscale objects with the potential to perform externally controlled motion in biological environments is one of the most sought-after objectives in nanotechnology. Different types of chemically and physically powered motors have been prepared at the macro- and microscale. However, the preparation of nanoscale objects with a complex morphology, and the potential for light-driven motion has remained elusive to date. Here, we go a step forward by designing a nanoscale hybrid with a propeller-resembling shape, which can be controlled by focused light under biological conditions. Our hybrid, hereafter 鈥淎u@DNA-origami鈥? consists of a spherical gold nanoparticle with self-assembled, biocompatible, two-dimensional (2D) DNA sheets on its surface. As a first step toward the potential utilization of these nanoscale objects as light-driven assemblies in biological environments, we show that they can be optically trapped, and hence translated and deposited on-demand, and that under realistic trapping conditions the thermally induced dehybridization of the DNA sheets can be avoided.

Keywords:

Gold nanoparticles; DNA origami; nanoscale hybrids; self-assembly; optical tweezers; optical manipulation; optical heating