C鈥揅 Bond Formation via Copper-Catalyzed Conjugate Addition Reactions to Enones in Water at Room Temperature

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• 作者：Bruce H. Lipshutz ; Shenlin Huang ; Wendy Wen Yi Leong ; Guofu Zhong ; Nicholas A. Isley
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：December 12, 2012
• 年：2012
• 卷：134
• 期：49
• 页码：19985-19988
• 全文大小：319K
• 年卷期：v.134,no.49(December 12, 2012)
• ISSN：1520-5126

文摘

Conjugate addition reactions to enones can now be done in water at room temperature with in situ generated organocopper reagents. Mixing an enone, zinc powder, TMEDA, and an alkyl halide in a micellar environemnt containing catalytic amounts of Cu(I), Ag(I), and Au(III) leads to 1,4-adducts in good isolated yields: no organometallic precursor need be formed.