Identification of 4,5-Dihydro-4-hydroxygeldanamycins As Shunt Products of Geldanamycin Biosynthesis

详细信息    查看全文

• 作者：Ting Li ; Siyang Ni ; Changhong Jia ; Hongyuan Wang ; Guizhi Sun ; Linzhuan Wu ; Maoluo Gan ; Guangzhi Shan ; Weiqing He ; Ling Lin ; Hongxia Zhou ; Yiguang Wang
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：August 24, 2012
• 年：2012
• 卷：75
• 期：8
• 页码：1480-1484
• 全文大小：217K
• 年卷期：v.75,no.8(August 24, 2012)
• ISSN：1520-6025

文摘

Two new geldanamycin (GDM) analogues, (4S)-4,5-dihydro-4-hydroxygeldanamycin (1) and (4R)-4,5-dihydro-4-hydroxygeldanamycin (2), were identified from Streptomyces hygroscopicus 17997. Compounds 1 and 2 were not normal intermediates of GDM biosynthesis but shunt products of C-4,5 oxidation catalyzed by GdmP, a cytochrome P450 oxidase acting as a desaturase in GDM biosynthesis. Preliminary assays implied that, compared with GDM, 1 and 2 exhibited decreased cytotoxicity.