Meroterpenoid and Diphenyl Ether Derivatives from Penicillium sp. MA-37, a Fungus Isolated from Marine Mangrove Rhizospheric Soil

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• 作者：Yi Zhang ; Xiao-Ming Li ; Zhuo Shang ; Chun-Shun Li ; Nai-Yun Ji ; Bin-Gui Wang
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：November 26, 2012
• 年：2012
• 卷：75
• 期：11
• 页码：1888-1895
• 全文大小：465K
• 年卷期：v.75,no.11(November 26, 2012)
• ISSN：1520-6025

文摘

Penicillium sp. MA-37, which was obtained from the rhizospheric soil of the mangrove plant Bruguiera gymnorrhiza, exhibited different chemical profiles in static and shaken fermentation modes. Three new meroterpenoid derivatives, 4,25-dehydrominiolutelide B (1), 4,25-dehydro-22-deoxyminiolutelide B (2), and isominiolutelide A (3), together with three known ones were characterized from its static fermentation, while three new diphenyl ether derivatives, namely, 螖^{1鈥?/sup>,3鈥?/sup>-1鈥?dehydroxypenicillide (4), 7-O-acetylsecopenicillide C (5), and hydroxytenellic acid B (6), along with five related metabolites were isolated from the shaken culture. The structures of these compounds were elucidated on the basis of spectroscopic analysis, and the structure of compound 2 was confirmed by X-ray crystallographic analysis. The absolute configurations of 1鈥?b>3 and 6 were determined by ECD and modified Mosher鈥檚 method, respectively. All isolated compounds were evaluated for brine shrimp lethality and antibacterial activity.}