Lasionectrin, a Naphthopyrone from a Lasionectria sp.

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• 作者：Noureddine El Aouad ; Guiomar P茅rez-Moreno ; Paula S谩nchez ; Juan Cantizani ; Francisco Javier Ortiz-L贸pez ; Jes煤s Mart铆n ; V铆ctor Gonz谩lez-Men茅ndez ; Luis M. Ruiz-P茅rez ; Dolores Gonz谩lez-Pacanowska ; Francisca Vicente ; Gerald Bills ; Fernando Reyes
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：June 22, 2012
• 年：2012
• 卷：75
• 期：6
• 页码：1228-1230
• 全文大小：188K
• 年卷期：v.75,no.6(June 22, 2012)
• ISSN：1520-6025

文摘

A new naphthopyrone derivative, lasionectrin (1), was isolated from fermentations of an Acremonium-like fungus provisionally identified as a Lasionectria sp. (Ascomycota, Hypocreales) and isolated from forest leaf litter from Equatorial Guinea. Its structure was determined by a combination of spectroscopic techniques, including UV, (+)-HRESIMS, and 1D and 2D NMR spectroscopy, and comparison with published data for related fungal metabolites. Compound 1 inhibited the growth of Plasmodium falciparum with an IC₅₀ value of 11 渭M.