Phenolic Glycosides from the Twigs of Salix glandulosa

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• 作者：Chung Sub Kim ; Oh Wook Kwon ; Sun Yeou Kim ; Sang Un Choi ; Jae Yoon Kim ; Ji Young Han ; Soo Im Choi ; Jong Gil Choi ; Ki Hyun Kim ; Kang Ro Lee
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：August 22, 2014
• 年：2014
• 卷：77
• 期：8
• 页码：1955-1961
• 全文大小：273K
• ISSN：1520-6025

文摘

As a part of an ongoing search for bioactive constituents from Korean medicinal plants, the phytochemical investigations of the twigs of Salix glandulosa afforded 12 new phenolic glycosides (1鈥?b>12) and a known analogue (13). The structures of 1鈥?b>13 were characterized by a combination of NMR methods (¹H and ¹³C NMR, ¹H鈥?sup>1H COSY, HMQC, and HMBC), chemical hydrolysis, and GC/MS. The absolute configuration of 13 [(1R,2S)-2-hydroxycyclohexyl-2鈥?O-trans-p-coumaroyl-尾-d-glucopyranoside] was determined for the first time. Compounds 1鈥?b>3, 6, and 7 exhibited inhibitory effects on nitric oxide production in lipopolysaccharide-activated murine microglial cells (IC₅₀ values in the range 6.6鈥?0.5 渭M).