Neonectrolide A, a New Oxaphenalenone Spiroketal from the Fungus Neonectria sp.

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• 作者：Jinwei Ren ; Fan Zhang ; Xiangyu Liu ; Li Li ; Gang Liu ; Xingzhong Liu ; Yongsheng Che
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：December 21, 2012
• 年：2012
• 卷：14
• 期：24
• 页码：6226-6229
• 全文大小：246K
• 年卷期：v.14,no.24(December 21, 2012)
• ISSN：1523-7052

文摘

Neonectrolide A (1), an oxaphenalenone spiroketal with the previously undescribed (5,8鈥?dimethyl-5鈥?oxo-3a鈥?4,5,5鈥?tetrahydro-3H,3鈥?i>H-spiro[furan-2,2鈥?isochromeno[3,4,5-def]chromene]-3鈥?yl)but-3-enoic acid skeleton, was isolated from cultures of the fungus Neonectria sp. Its absolute configuration was assigned by electronic circular dichroism (ECD) calculations. The skeleton of an oxaphenalenone fused with a 1,6-dioxaspiro[4.5]decane moiety in 1 could be derived from the coisolated putative precursors, corymbiferan lactone E (2) and 3-dehydroxy-4-O-acetylcephalosporolide C (3).