Chemoselective Cross-Coupling Reactions with Differentiation between Two Nucleophilic Sites on a Single Aromatic Substrate

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• 作者：Julian Linshoeft ; Annika C. J. Heinrich ; Stephan A. W. Segler ; Paul J. Gates ; Anne Staubitz
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：November 16, 2012
• 年：2012
• 卷：14
• 期：22
• 页码：5644-5647
• 全文大小：272K
• 年卷期：v.14,no.22(November 16, 2012)
• ISSN：1523-7052

文摘

A new thiophene building block, containing both a stannyl group and a boronic ester, was prepared. From this starting material, a general, nucleophile-selective one-pot reaction was developed, exploiting the different reactivities of the Stille and Suzuki鈥揗iyaura cross-coupling reactions. A series of aromatic electrophiles were used to demonstrate the high functional group tolerance.