Chirality Enriched (12,1) and (11,3) Single-Walled Carbon Nanotubes for Biological Imaging

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• 作者：Shuo Diao ; Guosong Hong ; Joshua T. Robinson ; Liying Jiao ; Alexander L. Antaris ; Justin Z. Wu ; Charina L. Choi ; Hongjie Dai
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：October 17, 2012
• 年：2012
• 卷：134
• 期：41
• 页码：16971-16974
• 全文大小：254K
• 年卷期：v.134,no.41(October 17, 2012)
• ISSN：1520-5126

文摘

The intrinsic band gap photoluminescence of semiconducting single-walled carbon nanotubes (SWNTs) makes them promising biological imaging probes in the second near-infrared (NIR-II, 1.0鈥?.4 渭m) window. Thus far, SWNTs used for biological applications have been a complex mixture of metallic and semiconducting species with random chiralities, preventing simultaneous resonant excitation of all semiconducting nanotubes and emission at a single well-defined wavelength. Here, we developed a simple gel filtration method to enrich semiconducting (12,1) and (11,3) SWNTs with identical resonance absorption at 808 nm and emission near 1200 nm. The chirality sorted SWNTs showed 5-fold higher photoluminescence intensity under resonant excitation of 808 nm than unsorted SWNTs on a per-mass basis. Real-time in vivo video imaging of whole mouse body and tumor vessels was achieved using a 6-fold lower injected dose of (12,1) and (11,3) SWNTs (3 渭g per mouse or 0.16 mg/kg of body weight vs 1.0 mg/kg for unsorted SWNTs) than a previous heterogeneous mixture, demonstrating the first resonantly excited and chirality separated SWNTs for biological imaging.