Multifunctional Fe3O4/TaOx Core/Shell Nanoparticles for Simultaneous Magnetic Resonance Imaging and X-ray Computed Tomography

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• 作者：Nohyun Lee ; Hye Rim Cho ; Myoung Hwan Oh ; Soo Hong Lee ; Kangmin Kim ; Byung Hyo Kim ; Kwangsoo Shin ; Tae-Young Ahn ; Jin Woo Choi ; Young-Woon Kim ; Seung Hong Choi ; Taeghwan Hyeon
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：June 27, 2012
• 年：2012
• 卷：134
• 期：25
• 页码：10309-10312
• 全文大小：296K
• 年卷期：v.134,no.25(June 27, 2012)
• ISSN：1520-5126

文摘

Multimodal imaging is highly desirable for accurate diagnosis because it can provide complementary information from each imaging modality. In this study, a sol鈥揼el reaction of tantalum(V) ethoxide in a microemulsion containing Fe₃O₄ nanoparticles (NPs) was used to synthesize multifunctional Fe₃O₄/TaO_x core/shell NPs, which were biocompatible and exhibited a prolonged circulation time. When the NPs were intravenously injected, the tumor-associated vessel was observed using computed tomography (CT), and magnetic resonance imaging (MRI) revealed the high and low vascular regions of the tumor.