A Novel Bitriazolyl Acyclonucleoside Endowed with Dual Antiproliferative and Immunomodulatory Activity

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• 作者：Yi Xia ; Menghua Wang ; Olivier Demaria ; Jingjie Tang ; Palma Rocchi ; Fanqi Qu ; Juan L. Iovanna ; Lena Alexopoulou ; Ling Peng
• 刊名：Journal of Medicinal Chemistry
• 出版年：2012
• 出版时间：June 14, 2012
• 年：2012
• 卷：55
• 期：11
• 页码：5642-5646
• 全文大小：306K
• 年卷期：v.55,no.11(June 14, 2012)
• ISSN：1520-4804

文摘

A novel bitriazolyl acyclonucleoside was discovered to exhibit powerful antiproliferative effects on different cancer cell lines through caspase-dependent apoptosis and at the same time stimulate the immune response in dendritic cells via Toll-like receptor 7 (TLR7) signaling. This promising compound with dual anticancer and immunomodulatory activity may represent a new generation of highly efficacious drug candidates for use in cancer therapy.