Asymmetric Allylic Alkylation of Pyrroles and 4,7-Dihydroindoles with Alkene鈥揚hosphine Ligands

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• 作者：Yilin Liu ; Ziping Cao ; Haifeng Du
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：May 4, 2012
• 年：2012
• 卷：77
• 期：9
• 页码：4479-4483
• 全文大小：285K
• 年卷期：v.77,no.9(May 4, 2012)
• ISSN：1520-6904

文摘

A palladium-catalyzed highly enantioselective allylic alkylation of pyrroles and 4,7-dihydroindoles has been successfully developed with the use of chiral alkene-phosphine hybrid ligands to furnish the desired products in high yields with excellent ee鈥檚. It is noteworthy that alkene鈥損hosphine ligands are much more effective than some other types of chiral ligands in this catalytic system.