Isoprenylated Flavonoid and Adipogenesis-Promoting Constituents of Dodonaea viscosa

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• 作者：Lai-Bin Zhang ; Jun Ji ; Chun Lei ; He-Yao Wang ; Qin-Shi Zhao ; Ai-Jun Hou
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：April 27, 2012
• 年：2012
• 卷：75
• 期：4
• 页码：699-706
• 全文大小：393K
• 年卷期：v.75,no.4(April 27, 2012)
• ISSN：1520-6025

文摘

Ten new isoprenylated flavonol derivatives, dodoviscins A鈥揓 (1鈥?b>10), and seven known compounds (11鈥?b>17) were isolated from the aerial parts of Dodonaea viscosa. Compounds 1, 2, 4, 5, 7鈥?b>9, 5,7,4鈥?trihydroxy-3鈥?5鈥?bis(3-methyl-2-buten-1-yl)-3-methoxyflavone (11), 5,7,4鈥?trihydroxy-3鈥?5鈥?bis(3-methyl-2-buten-1-yl)-3,6-dimethoxyflavone (12), 5,7,4鈥?trihydroxy-3鈥?(4-hydroxy-3-methylbutyl)-5鈥?(3-methyl-2-buten-1-yl)-3,6-dimethyoxyflavone (13), sakuranetin (14), and blumeatin (15) promoted adipocyte differentiation as characterized by increased triglyceride levels in 3T3L1 cells. Compounds 1, 13, and 15 also enhanced the accumulation of lipid droplets and induced upregulation of the expression of the adipocyte-specific genes aP2 and GLUT4.