A 1,4-Diphenyl-1,2,3-Triazole-Based 尾-Turn Mimic Constructed by Click Chemistry

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• 作者：Chun-Fang Wu ; Xin Zhao ; Wen-Xian Lan ; Chunyang Cao ; Jin-Tao Liu ; Xi-Kui Jiang ; Zhan-Ting Li
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：May 4, 2012
• 年：2012
• 卷：77
• 期：9
• 页码：4261-4270
• 全文大小：451K
• 年卷期：v.77,no.9(May 4, 2012)
• ISSN：1520-6904

文摘

A series of 1,4-diphenyl-1,2,3-triazole-incorporated amide derivatives have been designed and prepared. X-ray crystallographic and (1D and 2D) ¹H NMR studies reveal that these compounds fold into stable U-shaped conformations driven by three-center intramolecular C鈥揌路路路O hydrogen-bonding formed between the triazole C-5 H atom and the two ether O atoms. Such folded structures make this 1,4-diphenyl-1,2,3-triazole skeleton a good candidate to be used as 尾-turn mimic. To prove this, the formation of a 尾-hairpin structure induced by this 尾-turn motif has been further demonstrated.