Spiroindimicins A鈥揇: New Bisindole Alkaloids from a Deep-Sea-Derived Actinomycete

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• 作者：Wenjun Zhang ; Zhong Liu ; Sumei Li ; Tingting Yang ; Qingbo Zhang ; Liang Ma ; Xinpeng Tian ; Haibo Zhang ; Caiguo Huang ; Si Zhang ; Jianhua Ju ; Yuemao Shen ; Changsheng Zhang
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：July 6, 2012
• 年：2012
• 卷：14
• 期：13
• 页码：3364-3367
• 全文大小：232K
• 年卷期：v.14,no.13(July 6, 2012)
• ISSN：1523-7052

文摘

A PCR-based screening approach led to the identification of a deep-sea-derived Streptomyces sp. SCSIO 03032 capable of producing new bisindole alkaloids spiroindimicins A鈥揇 (1鈥?b>4). Structural elucidation of these compounds revealed the presence of unusual [5,6] or [5,5] spiro-ring containing skeletons. Spiroindimicins B鈥揇 (2鈥?b>4) with a [5,5] spiro-ring exhibited moderate cytotoxicities against several cancer cell lines.