Robust Enzymatic Resolution of 3-Fluoromandelic Acid with Lipase PS Supported on Celite

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• 作者：Javier Mendiola ; Susana Garc铆a-Cerrada ; 脫scar de Frutos ; Mar铆a Luz de la Puente
• 刊名：Organic Process Research & Development
• 出版年：2012
• 出版时间：July 20, 2012
• 年：2012
• 卷：16
• 期：7
• 页码：1312-1316
• 全文大小：208K
• 年卷期：v.16,no.7(July 20, 2012)
• ISSN：1520-586X

文摘

The resolution of different mandelic acids using the lipase PS 鈥淎mano鈥?SD enzyme is described. By supporting the lyophilized enzyme over Celite, both the activity and the stability of lipase PS in organic media were significantly improved, enabling the robust resolution scale-up of 3-fluoromandelic acid. The methodology was extended to produce a range of optically pure (R)-mandelic acids, avoiding tedious extractions or chromatography.