Aphanamixoid A, a Potent Defensive Limonoid, with a New Carbon Skeleton from Aphanamixis polystachya

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• 作者：Jie-Yun Cai ; Yu Zhang ; Shi-Hong Luo ; Duo-Zhi Chen ; Gui-Hua Tang ; Chun-Mao Yuan ; Ying-Tong Di ; Sheng-Hong Li ; Xiao-Jiang Hao ; Hong-Ping He
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：May 18, 2012
• 年：2012
• 卷：14
• 期：10
• 页码：2524-2527
• 全文大小：266K
• 年卷期：v.14,no.10(May 18, 2012)
• ISSN：1523-7052

文摘

Aphanamixoid A (1), a limonoid with a new carbon skeleton, along with its biogenetically related limonoid aphanamixoid B (2), was isolated from the leaves and twigs of Aphanamixis polystachya. Their structures with the absolute stereochemistry were determined by spectroscopic analysis, X-ray crystallography and computational methods. The significant antifeedant activity of 1 against the generalist plant-feeding insect Helicoverpa armigera (EC₅₀ = 0.015 渭mol/cm²) suggested it may be a potent defensive component of A. polystachya.