Photoluminescent Silicon Nanocrystal-Based Multifunctional Carrier for pH-Regulated Drug Delivery

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• 作者：Zhigang Xu ; Dongdong Wang ; Min Guan ; Xiaoyan Liu ; Yanjie Yang ; Dongfeng Wei ; Chunyan Zhao ; Haixia Zhang
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2012
• 出版时间：July 25, 2012
• 年：2012
• 卷：4
• 期：7
• 页码：3424-3431
• 全文大小：522K
• 年卷期：v.4,no.7(July 25, 2012)
• ISSN：1944-8252

文摘

A core鈥搒hell structured multifunctional carrier with nanocrystalline silicon (ncSi) as the core and a water-soluble block copolymer as the shell based on a poly(methacrylic acid) (PMAA) inner shell and polyethylene glycol (MPEG) outer shell (ncSi-MPM) was synthesized for drug delivery. The morphology, composition, and properties of the resulting ncSi-MPM were determined by comprehensive multianalytical characterization, including ¹H NMR spectroscopy, FTIR spectroscopy, XPS spectroscopy, TEM, DLS, and fluorescence spectroscopy analyses. The size of the resulting ncSi-MPM nanocarriers ranged from 40 to 110 nm under a simulated physiological environment. The loading efficiency of model drug doxorubicin (DOX) was approximately 6.1鈥?.4 wt % for ncSi-MPM and the drug release was pH controlled. Cytotoxicity studies demonstrated that DOX-loaded ncSi-MPM showed high anticancer activity against Hela cells. Hemolysis percentages (<2%) of ncSi-MPM were within the scope of safe values. Fluorescent imaging studies showed that the nanocarriers could be used as a tracker at the cellular level. Integration of the above functional components may result in ncSi-MPM becoming a promising multifunctional carrier for drug delivery and biomedical applications.

Keywords:

nanocrystalline silicon; cytotoxicity; controlled release; drug delivery