Streptocarbazoles A and B, Two Novel Indolocarbazoles from the Marine-Derived Actinomycete Strain Streptomyces sp. FMA

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• 作者：Peng Fu ; Chunli Yang ; Yi Wang ; Peipei Liu ; Yiming Ma ; Lei Xu ; Mingbo Su ; Kui Hong ; Weiming Zhu
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：May 4, 2012
• 年：2012
• 卷：14
• 期：9
• 页码：2422-2425
• 全文大小：241K
• 年卷期：v.14,no.9(May 4, 2012)
• ISSN：1523-7052

文摘

Streptocarbazoles A (1) and B (2), two novel indolocarbazoles featuring unprecedented cyclic N-glycosidic linkages between 1,3-carbon atoms of the glycosyl moiety and two indole nitrogen atoms of the indolocarbazole core, were isolated from the marine-derived actinomycetes strain Streptomyces sp. FMA. Their structures were established by spectroscopic methods, CD spectra, and ECD quantum mechanical calculations. Compound 1 was cytotoxic on HL-60 and A-549 cell lines and could arrest the cell cycle of Hela cells at the G<sub>2sub>/M phase.