Stereoselective Synthesis of Fluoro-homoneplanocin A as a Potential Antiviral Agent

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• 作者：Girish Chandra ; Mahesh S. Majik ; Ji Yee Lee ; Lak Shin Jeong
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：April 20, 2012
• 年：2012
• 卷：14
• 期：8
• 页码：2134-2137
• 全文大小：298K
• 年卷期：v.14,no.8(April 20, 2012)
• ISSN：1523-7052

文摘

Fluoro-homoneplanocin A (4) was synthesized from d-ribose, via the enyne ring-closing metathesis of 9, the stereoselective opening of epoxide 23a with fluoride, and a simultaneous oxidation鈥揺limination reaction. The key intermediate 8 is expected to serve as a versatile intermediate for the synthesis of carbanucleosides.