Synthesis of a Miniature Lipoarabinomannan

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• 作者：Jian Gao ; Guochao Liao ; Lizhen Wang ; Zhongwu Guo
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：February 7, 2014
• 年：2014
• 卷：16
• 期：3
• 页码：988-991
• 全文大小：429K
• ISSN：1523-7052

文摘

An analog of Mycobacterium tuberculosis lipoarabinomannan (LAM) has been synthesized containing the characteristic structures of all of its three major components; that is, a mannosylated phosphatidylinositol moiety, an oligomannan, and an oligoarabinan. A highly convergent strategy was developed that is applicable to the synthesis of other LAM analogs. The synthetic miniature LAM should be useful for various biological studies.