An Early Investigation of Ytterbium Nanocolloids for Selective and Quantitative 鈥淢ulticolor鈥?Spectral CT Imaging
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- 作者：Dipanjan Pan ; Carsten O. Schirra ; Angana Senpan ; Anne H. Schmieder ; Allen J. Stacy ; Ewald Roessl ; Axel Thran ; Samuel A. Wickline ; Roland Proska ; Gregory M. Lanza
- 刊名：ACS Nano
- 出版年：2012
- 出版时间：April 24, 2012
- 年：2012
- 卷：6
- 期：4
- 页码：3364-3370
- 全文大小：468K
- 年卷期：v.6,no.4(April 24, 2012)
- ISSN：1936-086X
文摘
We report a novel molecular imaging agent based on ytterbium designed for use with spectral 鈥渕ulticolor鈥?computed tomography (CT). Spectral CT or multicolored CT provides all of the benefits of traditional CT, such as rapid tomographic X-ray imaging, but in addition, it simultaneously discriminates metal-rich contrast agents based on the element鈥檚 unique X-ray K-edge energy signature. Our synthetic approach involved the use of organically soluble Yb(III) complex to produce nanocolloids of Yb of noncrystalline nature incorporating a high density of Yb (>500K/nanoparticle) into a stable metal particle. The resultant particles are constrained to vasculature (200 nm) and are highly selective for binding fibrin in the ruptured atherosclerotic plaque. Nanoparticles exhibited excellent signal sensitivity, and the spectral CT technique uniquely discriminates the K-edge signal (60 keV) of Yb from calcium (bones). Bioelimination and preliminary biodistribution reflected the overall safety and defined clearance of these particles in a rodent model.