One-Pot Three-Component Approach to the Synthesis of Polyfunctional Pyrazoles

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• 作者：Guolin Zhang ; Hangcheng Ni ; Wenteng Chen ; Jiaan Shao ; Huan Liu ; Binhui Chen ; Yongping Yu
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：December 6, 2013
• 年：2013
• 卷：15
• 期：23
• 页码：5967-5969
• 全文大小：188K
• 年卷期：v.15,no.23(December 6, 2013)
• ISSN：1523-7052

文摘

A simple, multicomponent, and straightforward reaction of vinyl azide, aldehyde, and tosylhydrazine affords the construction of 3,4,5-trisubstituted 1H-pyrazoles regioselectively in the presence of base with moderate to excellent yields. A range of functionality could be tolerated in this methodology, and a possible mechanism is proposed.