Brominated Aromatic Furanones and Related Esters from the Ascidian Synoicum sp.

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• 作者：Tae Hyung Won ; Ju-eun Jeon ; Seong-Hwan Kim ; So-Hyoung Lee ; Boon Jo Rho ; Dong-Chan Oh ; Ki-Bong Oh ; Jongheon Shin
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：December 28, 2012
• 年：2012
• 卷：75
• 期：12
• 页码：2055-2061
• 全文大小：311K
• 年卷期：v.75,no.12(December 28, 2012)
• ISSN：1520-6025

文摘

Nine new compounds, tris-aromatic furanones (1, 2, 3a, 3b, and 4) and related bis-aromatic diesters (5a, 5b, 6a, and 6b), are described from the ascidian Synoicum sp. collected off the coast of Chuja-do, Korea. The structures of these compounds, designated as cadiolides E and G鈥揑 (1鈥?b>4) and synoilides A and B (5 and 6), were determined by extensive spectroscopic analyses. The absolute configuration at the asymmetric center of cadiolide G (2) was assigned by ECD analysis. Of these new compounds, cadiolide I and the synoilides possess unprecedented carbon skeletons. Several of these compounds exhibited significant inhibition against diverse bacterial strains as well as moderate inhibition against the enzymes sortase A, isocitrate lyase, and Na⁺/K⁺-ATPase.